Cyanoacetic acid → N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)-2-cyanoacetamide
반응식
[NH2:1][C:2]1[CH:3]=[C:4]([S:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[CH:18][CH:17]=3)[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[C:28]([CH2:30][C:31](O)=[O:32])#[N:29]>>[O:25]1[CH2:24][CH2:23][N:22]([C:19]2[CH:18]=[CH:17][C:16]([NH:15][C:11]3[N:10]=[C:9]([S:8][C:4]4[CH:3]=[C:2]([NH:1][C:31](=[O:32])[CH2:30][C:28]#[N:29])[CH:7]=[CH:6][CH:5]=4)[CH:14]=[CH:13][N:12]=3)=[CH:21][CH:20]=2)[CH2:27][CH2:26]1참가 물질
3
실험 절차
In a procedure analogous to Example 15, reaction of 4-(3-aminophenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (50 mg, 0.13 mmol) and cyanoacetic acid (23 mg, 0.26 mmol) furnished the product (38 mg, 64%).
출처 및 근거
- ORD 기록
- ord-42c68a7ab55c4bd39d78df13aff3d05d
- 출처 데이터셋
- uspto-grants-2014_09