Benzaldehyde → Phenyl methoxymethyl cinnamonitrile

반응식

[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9](#[N:12])[CH:10]=[CH2:11].[CH3:13][O-:14].[Na+]>>[C:2]1([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([CH2:11][O:14][CH3:13])[C:9]#[N:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 240Benzaldehyde

HCID 7855Acrylonitrile

HCID 10942334Sodium Methoxide

생성물 1

HCID 67053415Phenyl methoxymethyl cinnamonitrile

실험 절차

In the procedure of Scheme C, benzaldehyde a is treated with acrylonitrile in the presence of sodium methoxide in step 1 to afford a phenyl methoxymethyl cinnamonitrile compound q, which in turn is reacted with guanidine in step 2 to yield the diaminopyrimidine r. Diamino pyrimidine r is a compound of formula (I) in which X is —CH2—, Y is —NH2 and R6, R7 and R8 are hydrogen.

출처 및 근거

ORD 기록: ord-a192201c1e914707b44acbd87a3f89da
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846705B2

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