Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4,5-Dihydroxy-pentanoic Acid Ethyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Ethyl 4-pentenoate | HCID 74786 | — |
| 반응물 | Methyl morpholine oxide | HCID 82029 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 촉매 | Osmium Tetroxide | HCID 30318 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4,5-Dihydroxy-pentanoic Acid Ethyl Ester | HCID 57093956 | 96% |
반응 단계
A solution of ethyl pent-4-enoate (11.7 g, 91.3 mmol) in tetrahydrofuran (420 mL) and water (40 mL) is treated with osmium tetroxide (1.0 g, 4.2 mmol) and 4-methylmorpholine N-oxide (32.5 mL, 50% in water) at room temperature and stired for 3 h, at which time no more starting material is detectable by TLC (SiO2, 2% methanol/dichloromethane, Rf=0.40). The mixture is concentrated in vacuo and the residue chromatographed on SiO2 (2% methanol/ethyl acetate) to afford the title compound 14.37 g (96%) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087626B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-57fb327c6424452aa0687ad11e5803ae |
| 출처 메모 | uspto-grants-2006_08 |