4-Benzoyldihydro-3H-furan-2-one → Dihydro-4-(phenylmethyl)-2(3H)-furanone

HRID 8195

반응식

HRID 8195 반응식
[C:1]([CH:9]1[CH2:13][O:12][C:11](=[O:14])[CH2:10]1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd](Cl)Cl>[CH2:1]([CH:9]1[CH2:13][O:12][C:11](=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 2297594-Benzoyldihydro-3H-furan-2-one

생성물 1

HCID 5150640Dihydro-4-(phenylmethyl)-2(3H)-furanone수율 54%

시약·촉매·용매 2

HCID 24290Palladium Chloride촉매HCID 887Methanol용매

실험 절차

To a solution of 4-benzoyl-dihydro-furan-2-one (5 g) in methanol (250 mL) in a Parr® reactor is added palladium chloride (0.25 g). The mixture is shaken under hydrogen (50 PSI) for 3 h. The mixture is filtered through a pad of Celite® (40 g) and the filtrate concentrated. The residue is chromatographed on SiO2 (10% ethyl acetate/hexanes, then 30% ethyl acetate/hexanes) to yield the title compound, (2.5 g, 34% from 3-benzoylpropionic acid), as a colorless liquid.

후처리

  1. filtrationThe mixture is filtered through a pad of Celite® (40 g)
  2. concentrationthe filtrate concentrated
  3. customThe residue is chromatographed on SiO2 (10% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-8b00c056f9bc46b2b56d079b375aa7cc
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087626B2

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