4-Acetoxy-3-phenyl-butyric Acid Methyl Ester → Dihydro-4-phenylfuran-2(3H)-one
반응식
COC(=O)C[CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6][O:7][C:8](=[O:10])[CH3:9]>O1CCOCC1.S(=O)(=O)(O)O>[C:11]1([CH:5]2[CH2:6][O:7][C:8](=[O:10])[CH2:9]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
4
반응 조건
- 온도
- 45 °C
실험 절차
A solution of 4-acetoxy-3-phenyl-butyric acid methyl ester, (4.5 g, 19.2 mmol) in 1,4-dioxane (29 mL) and sulfuric acid (29 mL) is stirred at room temperature for one hour then heated at 45° C. for 18 h. Volatile solvents are evaporated and the residue is extracted with toluene. The combined organic extracts are extracted with water and brine, filtered, and concentrated to yield the title compound, 2.2 g (71%), as a colorless liquid.
후처리
- customVolatile solvents are evaporated
- extractionthe residue is extracted with toluene
- extractionThe combined organic extracts are extracted with water and brine
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-c72e25f5b65a41dcba6135476c5cb717
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087626B2
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