Piperidine → 1-(4-Iodobenzoyl)piperidine
반응식
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>ClCCl>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:7])=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.
후처리
- temperatureThe reaction mixture was heated
- temperatureat reflux for 1.5 hour
- washThe organic layer was washed with an aqueous 1M HCl solution, brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-76702ff425514fff805c099782e85379
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846712B2
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