Piperidine → 1-(4-Iodobenzoyl)piperidine

HRID 82038

반응식

HRID 82038 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>ClCCl>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 743734-Iodobenzoyl chloride

생성물 1

HCID 51492041-(4-Iodobenzoyl)piperidine수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 1.5 hour
  3. washThe organic layer was washed with an aqueous 1M HCl solution, brine
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-76702ff425514fff805c099782e85379
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846712B2

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