2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → N-(5-{[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide

HRID 82083

반응식

HRID 82083 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][C:15]([NH:19]CC4C=CC(OC)=CC=4OC)=[N:14][C:13]=3[N:12]([C:31]([CH3:42])([CH3:41])[CH2:32][O:33][Si](C(C)(C)C)(C)C)[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[CH3:43][C:44]1[N:48]([CH2:49][C:50](O)=[O:51])[N:47]=[C:46]([C:53]([F:56])([F:55])[F:54])[CH:45]=1>>[NH2:19][C:15]1[N:16]=[CH:17][C:18]2[C:10]([C:8]([C:4]3[CH:3]=[C:2]([NH:1][C:50](=[O:51])[CH2:49][N:48]4[C:44]([CH3:43])=[CH:45][C:46]([C:53]([F:56])([F:55])[F:54])=[N:47]4)[CH:7]=[N:6][CH:5]=3)=[O:9])=[CH:11][N:12]([C:31]([CH3:41])([CH3:42])[CH2:32][OH:33])[C:13]=2[N:14]=1

참가 물질

3

반응물 2

HCID 5961182-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 70817384(5-aminopyridin-3-yl){7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-[(2,4-dimethoxybenzyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone

생성물 1

HCID 66571659N-(5-{[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide

실험 절차

The title compound was prepared according to the method described for Example 46 using (5-aminopyridin-3-yl){7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-[(2,4-dimethoxybenzyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (see Preparation 51) and (5-methyl-3-trifluoromethyl-pyrazol-1-yl)acetic acid (46.8 mg, 0.225 mmol) to afford the title compound as a brown solid in 79% yield, 82 mg.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-bf7fa4ad8e154b8eb454bf4f3e466c96
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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