Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluoroazetidine → 2-{3-[(3-fluoroazetidin-1-yl)methyl]phenyl}-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluoroazetidine | HCID 3603542 | — |
| 반응물 | 2-(3-formylphenyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide | HCID 86672072 | — |
| 생성물 | 2-{3-[(3-fluoroazetidin-1-yl)methyl]phenyl}-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide | HCID 70817487 | — |
반응 단계
The title compound was prepared according to the method described for Example 266 using 2-(3-formylphenyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide (Preparation 192, 60 mg, 0.14 mmol) and 3-fluoroazetidine to afford the title compound in 16% yield, 11 mg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846698B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-f48ee245a8074c2cb9304997d80fb423 |
| 출처 메모 | uspto-grants-2014_09 |