Morpholine → Formate

HRID 82094

반응식

HRID 82094 반응식
[CH:1]([C:3]1[CH:4]=[C:5]([CH2:9][C:10]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[C:17]([C:19]([C:21]3[C:29]4[CH:28]=[N:27][CH:26]=[N:25][C:24]=4[N:23]([CH:30]([CH3:32])[CH3:31])[CH:22]=3)=[O:20])[CH:18]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1)=[O:2].[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH:19]([OH:20])=[O:36].[CH:30]([N:23]1[C:24]2[N:25]=[CH:26][N:27]=[CH:28][C:29]=2[C:21]([C:19]([C:17]2[CH:18]=[C:13]([NH:12][C:10](=[O:11])[CH2:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][N:33]4[CH2:38][CH2:37][O:36][CH2:35][CH2:34]4)[CH:4]=3)[CH:14]=[N:15][CH:16]=2)=[O:20])=[CH:22]1)([CH3:31])[CH3:32].[CH:37]([O-:36])=[O:2]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 866720722-(3-formylphenyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide

생성물 2

HCID 283FormateHCID 70817459N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}-2-[3-(morpholin-4-ylmethyl)phenyl]acetamide formate salt

실험 절차

The title compound was prepared according to the method described for Example 266 using 2-(3-formylphenyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide (Preparation 192, 60 mg, 0.14 mmol) and morpholine to afford the title compound as a formate salt in 30% yield, 21 mg.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-8c4510a8fcba4267b49c6401294d1ada
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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