1,4-Dioxane hydrochloride → 2-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide

HRID 82119노트

반응식

HRID 82119 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:32]C(=O)OC(C)(C)C)[C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=3)=[O:19])[CH:17]=2)=[O:10])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[NH2:32][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:9]([NH:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]2[C:28]3[CH:27]=[N:26][CH:25]=[N:24][C:23]=3[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=2)=[O:19])[CH:17]=1)=[O:10]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70856232tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate

생성물 1

HCID 708179792-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide수율 8%

실험 절차

To tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate (Preparation 299, 64 mg, 0.11 mmol) was added 4M HCl/dioxane (5 mL) and the reaction stirred at room temperature for 18 hours. The mixture was evaporated in vacuo and purified by preparative reverse phase HPLC to give the title compound as a beige solid in 8% yield, 4 mg.

후처리

  1. customThe mixture was evaporated in vacuo
  2. custompurified by preparative reverse phase HPLC

출처 및 근거

ORD 기록
ord-af974f211c1f4c598f549ccae4a71d68
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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