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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 82127생성일: 2026년 10월 25일

2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → N-[2-Ethoxy-5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetamide

https://huagongshe.com/reaction/82127

반응식

참여 물질

역할이름HCID투입량
반응물2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 596118—
반응물(5-Amino-6-ethoxy-pyridin-3-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanoneHCID 70817179—
생성물N-[2-Ethoxy-5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetamideHCID 70817762—

반응 단계

The title compound was prepared according to the method described for Example 1 using (5-Amino-6-ethoxy-pyridin-3-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone (Preparation 242) and (5-Methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid to afford the title compound as off white solid in 50% yield, 40 mg.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08846698B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-e1f7abc9b8df459e881d52131cd44450
출처 메모uspto-grants-2014_09