(4-Chlorophenyl)acetic acid → N-[5-(7-tert-Butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-chloro-phenyl)-N-methyl-acetamide

HRID 82134노트

반응식

HRID 82134 반응식
[C:1]([N:5]1[C:9]2[N:10]=[CH:11][N:12]=[CH:13][C:8]=2[C:7]([C:14]([C:16]2[CH:17]=[N:18][CH:19]=[C:20]([NH:22][CH3:23])[CH:21]=2)=[O:15])=[CH:6]1)([CH3:4])([CH3:3])[CH3:2].[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]([OH:34])=O)=[CH:27][CH:26]=1>>[C:1]([N:5]1[C:9]2[N:10]=[CH:11][N:12]=[CH:13][C:8]=2[C:7]([C:14]([C:16]2[CH:21]=[C:20]([N:22]([CH3:23])[C:32](=[O:34])[CH2:31][C:28]3[CH:27]=[CH:26][C:25]([Cl:24])=[CH:30][CH:29]=3)[CH:19]=[N:18][CH:17]=2)=[O:15])=[CH:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 70817575(7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-methylamino-pyridin-3-yl)-methanone

생성물 1

HCID 70817730N-[5-(7-tert-Butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-chloro-phenyl)-N-methyl-acetamide

실험 절차

The title compound was prepared according to the method described for Example 1 using (7-tert-Butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-methylamino-pyridin-3-yl)-methanone (Preparation 187) and (4-chloro-phenyl)-acetic acid to afford the title compound as off white solid in 45% yield, 21 mg.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-d73bc0288f7f4904a66b7123dd131e7f
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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