(R)-(-)-2-Amino-1-propanol → (2R)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

HRID 82140

반응식

HRID 82140 반응식
Cl[C:2]1[C:7]([CH2:8][CH:9]=O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[NH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[Cl:11][C:6]1[C:7]2[CH:8]=[CH:9][N:12]([C@H:13]([CH3:16])[CH2:14][OH:15])[C:2]=2[N:3]=[CH:4][N:5]=1

참가 물질

3

반응물 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 13989292(4,6-Dichloropyrimidin-5-yl)acetaldehyde

생성물 1

HCID 86672074(2R)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

실험 절차

The title compound was prepared according to the method described for Preparation 1 using (4,6-dichloropyrimidin-5-yl)acetaldehyde and (R)-2-amino-1-propanol to afford the title compound as a yellow solid in 100% yield, 11.12 g.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-724f7da987ad489a87231b8b832ce6de
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

연결된 노트

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