Trifluoroacetic acid → 2-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid

HRID 82172노트

반응식

HRID 82172 반응식
FC(F)(F)C(O)=O.C([O:12][C:13](=[O:24])[CH2:14][N:15]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[N:16]1)(C)(C)C>C(Cl)Cl>[F:22][C:20]([F:21])([F:23])[C:18]1[CH:17]=[N:16][N:15]([CH2:14][C:13]([OH:24])=[O:12])[CH:19]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 70847644HCID 70847644, 화합물

생성물 1

HCID 641764822-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid수율 79%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

Trifluoroacetic acid (10 mL) was added to tert-butyl[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetate (1.3 g, 5.2 mmol) (see Preparation 84) in dry DCM (10 mL) and the mixture was stirred for 18 hours at 25° C. Then the mixture was evaporated in vacuo and the residue was purified by trituration with diethyl ether:pentane (1:9, 2 mL) to afford the title compound as a white solid in 79% yield, 800 mg.

후처리

  1. customThen the mixture was evaporated in vacuo
  2. customthe residue was purified by trituration with diethyl ether:pentane (1:9, 2 mL)

출처 및 근거

ORD 기록
ord-14e98db93a614314ae13268224b1a2f8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

반응 노트

불러오는 중…