참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| 반응물 | Cyclopropanecarboxamide | HCID 80376 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Ethyl 2-(2-cyclopropyloxazol-4-yl)acetate | HCID 86672106 | 50% |
반응 단계
Ethyl 4-chloroacetoacetate (20.0 g, 122.0 mmol) was added to cyclopropanecarboxamide (3.52 g, 41.5 mmol) in toluene (100 mL) and 1,4-dioxane (100 mL). The mixture was refluxed at 120° C. for 17 hours then evaporated in vacuo. The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc) to afford the title compound as a white solid in 50% yield, 4.00 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846698B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-31cc3862d3244285a6a75e5c3f5b4c7c |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
