Thionyl Chloride → 4-(chloromethyl)-1-isopropyl-5-(trifluoromethyl)-1H-pyrazole
반응식
S(Cl)([Cl:3])=O.[CH:5]([N:8]1[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([CH2:17]O)[CH:10]=[N:9]1)([CH3:7])[CH3:6]>C(Cl)Cl>[Cl:3][CH2:17][C:11]1[CH:10]=[N:9][N:8]([CH:5]([CH3:7])[CH3:6])[C:12]=1[C:13]([F:16])([F:15])[F:14]참가 물질
4
실험 절차
Thionyl chloride (5.26 mL, 72 mmol) was added to [1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methanol (Preparation 183, 7.5 g, 36 mmol) in DCM (75 mL) at 0° C. and the mixture was stirred for 2 hours. The mixture was diluted with DCM (30 mL) and the organic phase was washed with water (75 mL), brine (75 mL) and dried over sodium sulphate. The filtrate was evaporated in vacuo to afford 4-(chloromethyl)-1-isopropyl-5-(trifluoromethyl)-1H-pyrazole in 86% yield, 7 g.
후처리
- washthe organic phase was washed with water (75 mL), brine (75 mL)
- dry with materialdried over sodium sulphate
- customThe filtrate was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-db770f9f3e0041fb8531c2a83e9ab379
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846698B2
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