Ethyl 4-nitrophenylacetate → p-Aminophenylacetic acid ethyl ester

HRID 82288노트

반응식

HRID 82288 반응식
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH2:12])=[CH:10][CH:11]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 79517Ethyl 4-nitrophenylacetate

생성물 1

HCID 225219p-Aminophenylacetic acid ethyl ester수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2×20 mL) and the filtrate was evaporated in vacuo to afford the title compound as an oil in 96% yield, 2.8 g.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed with methanol (2×20 mL)
  3. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-fe07bca9abc34804884d77575928a0e0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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