참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4-Chloro-3-Fluorobenzaldehyde | HCID 2724985 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 3-(4-chloro-3-fluorophenyl)-2-cyanoacrylate | HCID 67338173 | 88% |
반응 단계
4-Chloro-3-fluorobenzaldehyde (1.0 g, 6.3 mmol) was added to a solution of ethyl 2-cyanoacetate (0.71 g, 6.3 mmol) and piperidine (0.081 ml, 0.82 mmol) in toluene (10 mL) at room temperature. The mixture was heated at 100° C. for 7 hours. Upon cooling to room temperature, the mixture was concentrated in vacuo and rinsed with hexane to give ethyl 3-(4-chloro-3-fluorophenyl)-2-cyanoacrylate (1.4 g, 88%). LCMS (APCI+) [M+H]+253.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846681B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ec39c84d5e1f4e72b64dbc6f9ace4b66 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
