N-methyl-2-pyrrolidone → 8-((6-amino-4-chloro-2-pyridinyl)amino)-6-((trans-4-aminocyclohexyl)amino)-N-(3-fluoro-4-pyridinyl)imidazo[1,2-b]pyridazine-3-carboxamide

HRID 824068

반응식

HRID 824068 반응식
[CH3:38][N:39]1[CH2:40][CH2:41][CH2:42][C:43]1=[O:44].[CH:30]1([NH2:37])[CH2:31][CH2:32][CH:33]([NH2:36])[CH2:34][CH2:35]1.[NH2:1][c:2]1[cH:3][c:4]([Cl:29])[cH:5][c:6]([NH:8][c:9]2[c:10]3[n:11]([n:12][c:13]([Cl:15])[cH:14]2)[c:16]([C:19](=[O:20])[NH:21][c:22]2[c:23]([F:28])[cH:24][n:25][cH:26][cH:27]2)[cH:17][n:18]3)[n:7]1>>[NH2:1][c:2]1[cH:3][c:4]([Cl:29])[cH:5][c:6]([NH:8][c:9]2[c:10]3[n:11]([n:12][c:13]([NH:36][CH:33]4[CH2:32][CH2:31][CH:30]([NH2:37])[CH2:35][CH2:34]4)[cH:14]2)[c:16]([C:19](=[O:20])[NH:21][c:22]2[c:23]([F:28])[cH:24][n:25][cH:26][cH:27]2)[cH:17][n:18]3)[n:7]1

참가 물질

4

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 183741,4-DiaminocyclohexaneHCID 596243518-(6-amino-4-chloropyridin-2-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

생성물 1

HCID 596244188-((6-amino-4-chloro-2-pyridinyl)amino)-6-((trans-4-aminocyclohexyl)amino)-N-(3-fluoro-4-pyridinyl)imidazo[1,2-b]pyridazine-3-carboxamide

출처 및 근거

ORD 기록
ord-917fdd6a32f4409aaa992f6fc478957c
출처 데이터셋
Test data from https://doi.org/10.1039/C8SC04228D

연결된 노트

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