Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate → Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate

HRID 82411노트

반응식

HRID 82411 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.O([Si](C)(C)C)[K:21]>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:17])([F:18])[F:19])[C:9]([O-:11])=[O:10])=[CH:6][CH:7]=1.[K+:21]

참가 물질

4

반응물 2

HCID 66617993Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoateHCID 178504318HCID 178504318, 화합물

생성물 1

HCID 66617976Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate수율 118%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (235 mg, 0.795 mmol) in TI-IF (3.0 mL) was treated with KOTMS (153 mg, 1.19 mmol) at room temperature. The reaction was allowed to stir 18 hours to completion, and the mixture was diluted with ether. The resulting precipitate was isolated by filtration and placed under high vacuum for two hours to afford the potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (299 mg, 118%, excess salts) as a white solid. LCMS (APCI+) m/z 282.0 [M+H]+.

후처리

  1. customThe resulting precipitate was isolated by filtration
  2. waitplaced under high vacuum for two hours

출처 및 근거

ORD 기록
ord-822a7d744a204daf8b5797e1f101c571
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846681B2

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