Thionyl bromide → 4-(Bromomethyl)-2-chloropyridine

HRID 82454

반응식

HRID 82454 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[CH:4][N:3]=1.S(Br)([Br:12])=O>ClCCl>[Br:12][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1

참가 물질

4

반응물 2

HCID 68176Thionyl bromideHCID 7062237(2-Chloropyridin-4-yl)methanol

생성물 1

HCID 129548074-(Bromomethyl)-2-chloropyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-chloropyridine-4-methanol (1.02 g, 7.10 mmol) in 15 mL of dichloromethane was added thionyl bromide (1.77 g, 8.53 mmol) dropwise. After 15 min, the reaction was quenched with saturated aqueous ammonium chloride. The organic solution was washed 2× with water, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 4-(bromomethyl)-2-chloropyridine that gave a mass ion (ES+) of 208.0 for [M+H]+.

후처리

  1. customthe reaction was quenched with saturated aqueous ammonium chloride
  2. washThe organic solution was washed 2× with water
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-17d0cd4dc70248268dec5a69fed8b35c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846702B2

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