6-Chloronicotinoyl Chloride → N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamide

반응식

[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([NH2:11])[n:8][cH:9][cH:10]1.[Cl:12][c:13]1[n:14][cH:15][c:16]([C:17](=[O:18])[Cl:19])[cH:20][cH:21]1.[Cl:22][c:23]1[cH:24][cH:25][c:26]([C:27]([NH:28][c:29]2[cH:30][cH:31][c:32]([I:33])[c:34]([CH3:35])[cH:36]2)=[O:37])[cH:38][n:39]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([NH:11][C:17]([c:16]2[cH:15][n:14][c:13]([Cl:12])[cH:21][cH:20]2)=[O:18])[n:8][cH:9][cH:10]1

참가 물질

반응물 3

HCID 27821656-Chloronicotinoyl Chloride

HCID 124506314-tert-Butylpyrimidin-2-amine

HCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

생성물 1

HCID 59318000N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamide

출처 및 근거

ORD 기록: ord-5af1a173733a4385af87997e239de7d4
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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