참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | NADP nicotinamide-adenine-dinucleotide phosphate | HCID 5886 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 반응물 | Monobasic potassium phosphate | HCID 516951 | — |
| 반응물 | benzyl [(3S)-4-oxotetrahydro-2H-pyran-3-yl]carbamate | HCID 60209900 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | benzyl N-[(3S,4S)-4-hydroxytetrahydropyran-3-yl]carbamate | HCID 60209901 | — |
반응 단계
To a solution of potassium dihydrogen phosphate (62.7 g, 0.461 mol) in 3.6 L of water was added phosphoric acid to pH=7.0. To this solution was added glucose (112 g, 0.622 mol), NADP (3.6 g), GDH-103 (1.8 g), KRED 119 (3.6 g), and crude benzyl [(3S)-4-oxotetrahydro-2H-pyran-3-yl]carbamate (103.4 g, 0.4148 mol). After 17 h, the reaction was adjusted to pH 6.5 with 5 N NaOH. A white solid was collected via filtration and washed 2× with water (200 mL). The solid was suspended in 600 mL of toluene and stirred with an overhead stirrer at 105° C. for 1 h, then cooled to rt. A white solid was collected via filtration and washed with toluene (200 mL) to provide benzyl [(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]carbamate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846702B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-547bc1aef0bd4fe4aab1a26dd00d7236 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
