참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nicotinic Acid | HCID 938 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | L-Isoleucine, methyl ester | HCID 75735 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methyl-2-[pyridine-3-carbonyl-amino]-pentanoic acid methyl ester | HCID 67347281 | 72% |
반응 단계
To a solution of nicotinic acid (2.0 g, 16.5 mmol) in DCM (20 mL), was added N-methylmorpholine (6.9 mL, 49.5 mmol), EDCI.HCl (6.3 g, 33.0 mmol) and isoleucine methyl ester (3.0 g, 16.5 mmol). The mixture was allowed to stir at room temperature (25° C.) over 2.5 h under nitrogen atmosphere. The resulting mixture was diluted with DCM (200 mL), washed with water (3×100 mL) and dried over sodium sulphate. The crude product obtained upon evaporation of the solvent was further purified by silica gel column chromatography to obtain product as yellow solid (2.9 g, 72%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846721B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ee4fc42b7a164947bbb6b4388f3bd1df |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
