Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 82549생성일: 2026년 10월 25일
Cesium carbonate → tert-butyl {4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]phenyl}carbamate
https://huagongshe.com/reaction/82549
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | N-Boc-4-hydroxyaniline | HCID 2756771 | — |
| 반응물 | 2-Chloro-1-[[2-(trimethylsilanyl)ethoxy]methyl]-benzimidazole | HCID 59752898 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | tert-butyl {4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]phenyl}carbamate | HCID 58577462 | 100.5% |
반응 단계
A mixture of 2-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole (8.7 g), tert-butyl 4-hydroxyphenylcarbamate (6.4 g) and cesium carbonate (20 g) in DMF (60 mL) was stirred at 60° C. for 24 h. After cooling to room temperature, to the mixture was added SiO2, the mixture was evaporated, and then the residue was purified by column chromatography (silica gel, eluted with 0%-50% EtOAc in hexane) to give tert-butyl {4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]phenyl}carbamate (14 g) as brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846713B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-fc024d9fdbf44f528281c759698cd5ce |
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| 출처 메모 | uspto-grants-2014_09 |
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