6,7-Difluoro-1,2,3,4-tetrahydroquinoline → [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(6,7-difluoro-3,4-dihydro-2H-quinolin-1-yl)-methanone

반응식

[Cl:13][c:14]1[c:15]([O:16][c:17]2[c:18]([C:23](=[O:24])[N:25]3[c:26]4[c:27]([cH:28][cH:29][cH:30][cH:31]4)[CH2:32][CH2:33][CH2:34]3)[cH:19][n:20][cH:21][cH:22]2)[cH:35][c:36]([Cl:39])[cH:37][cH:38]1.[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][c:11]1[F:12])[NH:8][CH2:7][CH2:6][CH2:5]2>>[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][c:11]1[F:12])[N:8]([C:23]([c:18]1[c:17]([O:16][c:15]3[c:14]([Cl:13])[cH:38][cH:37][c:36]([Cl:39])[cH:35]3)[cH:22][cH:21][n:20][cH:19]1)=[O:24])[CH2:7][CH2:6][CH2:5]2

참가 물질

반응물 2

HCID 167848686,7-Difluoro-1,2,3,4-tetrahydroquinoline

HCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

생성물 1

HCID 53311782[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(6,7-difluoro-3,4-dihydro-2H-quinolin-1-yl)-methanone

출처 및 근거

ORD 기록: ord-eaa0b1fcf5db4e50903a46c4b1442689
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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