N-Methylbenzylamine → HCID 58577265, 화합물

반응식

[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=1>>[CH2:3]([N:2]([CH3:1])[C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 7669N-Methylbenzylamine

HCID 5549883-Chloro-2-nitropyridine

생성물 1

HCID 58577265HCID 58577265, 화합물

반응 조건

온도: 60 °C

실험 절차

The mixture of N-methylbenzylamine (6.085 mL), TEA (13.19 ml) and 3-chloro-2-nitropyridine (5 g) was stirred at 60° C. under N2 overnight. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane) to give N-benzyl-N-methyl-2-nitropyridin-3-amine (2.6 g) as dark yellow oil.

후처리

concentrationThe reaction mixture was concentrated in vacuo
customThe residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane)

출처 및 근거

ORD 기록: ord-33f708dc08ce46dbbef3d4e131f9ace7
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846713B2

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