1,1'-Carbonyldiimidazole → 3-Methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

HRID 82584노트

반응식

HRID 82584 반응식
[CH3:1][NH:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][N:4]=1.C1N=CN([C:15](N2C=NC=C2)=[O:16])C=1>C1COCC1>[CH3:1][N:2]1[C:3]2=[N:4][CH:5]=[CH:6][CH:7]=[C:8]2[NH:9][C:15]1=[O:16]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 123436692-N-methylpyridine-2,3-diamine

생성물 1

HCID 9112333-Methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one수율 82.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of N2-methylpyridine-2,3-diamine (7 g) and CDI (13.82 g) in THF (100 mL) was refluxed for 5 h. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (NH silica gel, eluted with 0%-100% EtOAc in hexane) to give 3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (7 g) as a light brown solid.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe residue was purified by column chromatography (NH silica gel, eluted with 0%-100% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-41b77120abdc4b4cb6c027d6b8d144d6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846713B2

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