N-methyl-2-pyrrolidone → 3-(7-bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-4-ol

HRID 8263

반응식

HRID 8263 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:12]3[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:15][N:14]4[CH2:23][CH2:24][CH:25](Cl)[C:13]=34)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.CN1C(=[O:33])CCC1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:12]3[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:15][N:14]4[CH2:23][CH2:24][CH:25]([OH:33])[C:13]=34)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 13387N-methyl-2-pyrrolidoneHCID 101132117-Bromo-4-(4-chloro-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline

생성물 1

HCID 101795483-(7-bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-4-ol

실험 절차

A solution of 7-bromo-4-(4-chloro-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline (765.0 mg, 1.80 mmol) in 15% (v/v) aqueous N-methyl pyrrolidinone (15 mL) is heated at 120° C. for 18 h. The mixture is concentrated in vacuo and the residue chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane) to yield a yellow solid, 408.0 mg (60%).

후처리

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane)
  3. customto yield a yellow solid, 408.0 mg (60%)

출처 및 근거

ORD 기록
ord-de463c15ccd6498c993b031cb7ea560c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087626B2

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