Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → Methyl 2-fluoro-4-(trifluoromethyl)nicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid | HCID 28307766 | — |
| 생성물 | Methyl 2-fluoro-4-(trifluoromethyl)nicotinate | HCID 58577652 | 99.9% |
반응 단계
To a mixture of 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid (1.06 g) and K2CO3 (0.701 g) in DMF(dry) (10 mL) was added MeI (0.317 ml). The mixture was stirred at room temperature for 3 h. The mixture was directly purified by column chromatography (silica gel, EtOAc/hexane) to give the title compound (1.13 g, containing EtOAc and hexane, ca. 75% purity).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846713B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-6302aff528d24ad7b6dc61b4c1fada97 |
| 출처 메모 | uspto-grants-2014_09 |