Trifluoroacetic acid → N-((7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide

HRID 82871노트

반응식

HRID 82871 반응식
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][NH:19][S:20]([CH2:23][CH:24]3[CH2:26][CH2:25]3)(=[O:22])=[O:21])[CH:16]=2)[CH2:11][CH2:10][CH:9]1[NH:27]C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:27][CH:9]1[CH:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:17]2[CH:16]=[C:15]([CH2:18][NH:19][S:20]([CH:23]3[CH2:25][CH2:26][CH2:24]3)(=[O:22])=[O:21])[CH:14]=[CH:13][C:12]=2[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86685686tert-Butyl 1-benzyl-7-((cyclopropylmethylsulfonamido)methyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

생성물 1

HCID 46870540N-((7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 1-benzyl-7-((cyclopropylmethylsulfonamido)methyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (0.602 g, 1.242 mmol) was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (0.5 mL, 6.49 mmol) and stirred overnight at room temperature. The solution was evaporated and partitioned between saturated aqueous NaHCO3 and ethyl acetate. Water was extracted with ethyl acetate (2×30 mL). The collected organic extracts were dried on MgSO4 and evaporated under reduced pressure to give a brown oil. Product was obtained as a brown oil (0.470 g, 1.22, 98%).

후처리

  1. customThe solution was evaporated
  2. custompartitioned between saturated aqueous NaHCO3 and ethyl acetate
  3. extractionWater was extracted with ethyl acetate (2×30 mL)
  4. customThe collected organic extracts were dried on MgSO4
  5. customevaporated under reduced pressure
  6. customto give a brown oil
  7. customProduct was obtained as a brown oil (0.470 g, 1.22, 98%)

출처 및 근거

ORD 기록
ord-954704e9dd5849fa8100e1310a85115c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846741B2

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