Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Thiophenesulfonyl chloride | HCID 85518 | — |
| 반응물 | 1-(3-Aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine | HCID 22015499 | — |
| 생성물 | 3-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide | HCID 86605127 | 22% |
반응 단계
A solution of 1-(3-aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine (153 mg, 0.5 mmol) in pyridine (2 mL) was treated with 2-thiophenesulphonyl chloride (91 mg, 0.5 mmol), stirred at room temperature for 16 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (MeOH:DCM, 1:99) to give the title compound (49 mg, 22%) as a cream solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087754B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-df00543d4c174ad98bde971596d1cfc6 |
| 출처 메모 | uspto-grants-2006_08 |