참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(2-Thienyl)propanoic acid | HCID 703169 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(Thiophen-2-yl)propan-1-ol | HCID 13109866 | — |
반응 단계
Borane methylsulfide complex (6.4 mL, 12.8 mmol) was added to a solution of 3-(2-thienyl)propanoic acid (1.0 g, 6.4 mmol) in THF (18 mL) at 0° C. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature for 3 additional hours. After cooling down to 0° C., the reaction was quenched by addition of a saturated solution of potassium carbonate (5 mL). The aqueous layer was separated and extracted with ethyl acetate (2×15 mL) and diethyl ether (2×15 mL). The combined organic phases were dried over sodium sulfate, filtered and concentrated to dryness. The title compound was obtained as a colorless oil (1.0 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846711B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-63cc154a584f4c0dbb69321ff3330cc5 |
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| 출처 메모 | uspto-grants-2014_09 |
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