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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 82983생성일: 2026년 10월 24일

3-(2-Thienyl)propanoic acid → 3-(Thiophen-2-yl)propan-1-ol

https://huagongshe.com/ko/reaction/82983

반응식

참여 물질

역할이름HCID투입량
반응물3-(2-Thienyl)propanoic acidHCID 703169—
용매TetrahydrofuranHCID 8028—
생성물3-(Thiophen-2-yl)propan-1-olHCID 13109866—

반응 조건

온도0 °C

반응 단계

Borane methylsulfide complex (6.4 mL, 12.8 mmol) was added to a solution of 3-(2-thienyl)propanoic acid (1.0 g, 6.4 mmol) in THF (18 mL) at 0° C. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature for 3 additional hours. After cooling down to 0° C., the reaction was quenched by addition of a saturated solution of potassium carbonate (5 mL). The aqueous layer was separated and extracted with ethyl acetate (2×15 mL) and diethyl ether (2×15 mL). The combined organic phases were dried over sodium sulfate, filtered and concentrated to dryness. The title compound was obtained as a colorless oil (1.0 g, 100%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08846711B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-63cc154a584f4c0dbb69321ff3330cc5
출처 메모uspto-grants-2014_09