Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 2-(2',6'-Difluorophenyl)-1,8-naphthyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1-(2,6-Difluorophenyl)ethan-1-one | HCID 83643 | — |
| 반응물 | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(2',6'-Difluorophenyl)-1,8-naphthyridine | HCID 15790208 | 79% |
반응 단계
2-Aminonicotinaldehyde (2.44 g, 20 mmol) and 2,6-difluoroacetophenone (3.28 g, 21 mmol) are dissolved in 20 ml of MeOH. The mixture is treated dropwise with 3 ml of 40% KOH and, after the exothermic reaction has subsided, it is poured onto water and the residue which is deposited is filtered off with suction. 3.8 g (79% yield) of the desired product are obtained. M.p. 100°-103° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723413 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-819df65591774363bb9b76f5effae47b |
| 출처 메모 | uspto-grants-1998_03 |