Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 2-(2-Thiazolyl)-1,8-naphthyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-Acetylthiazole | HCID 520108 | — |
| 반응물 | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(2-Thiazolyl)-1,8-naphthyridine | HCID 15790207 | 46.5% |
반응 단계
2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160°-165° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723413 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-6da8fccbc46d48d9b47085df7224e0c2 |
| 출처 메모 | uspto-grants-1998_03 |