Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol → 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-nitro-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol | HCID 2776149 | — |
| 반응물 | HCID 178526703 | HCID 178526703 | — |
| 생성물 | 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-nitro-pyridine | HCID 68444760 | 37% |
반응 단계
As described for example 4, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (200 mg, 1.06 mmol) was converted using 2-hydroxy-5-nitro-pyridine instead of 2-hydroxy-5-trifluoromethylpyridine to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=80:0:20 to 50:30:20, 122 mg, 37%) which was obtained as a white solid. MS: m/e=312.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-034cd51963e7466d8b116b6ceaab4753 |
| 출처 메모 | uspto-grants-2014_09 |