Raloxifene → 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

반응식

[C:44]([CH3:45])([CH3:46])([CH3:47])[Si:48]([CH3:49])([CH3:50])[Cl:51].[CH3:35][N:36]([c:37]1[cH:38][cH:39][cH:40][cH:41][n:42]1)[CH3:43].[OH:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:18](=[O:19])[c:20]3[cH:21][cH:22][c:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]4)[cH:24][cH:25]3)[c:10]3[c:11]([s:12]2)[cH:13][c:14]([OH:17])[cH:15][cH:16]3)[cH:6][cH:7]1>>[O:1]([c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:18](=[O:19])[c:20]3[cH:21][cH:22][c:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]4)[cH:24][cH:25]3)[c:10]3[c:11]([s:12]2)[cH:13][c:14]([OH:17])[cH:15][cH:16]3)[cH:6][cH:7]1)[Si:48]([C:44]([CH3:45])([CH3:46])[CH3:47])([CH3:49])[CH3:50]

참가 물질

반응물 3

HCID 5035Raloxifene

HCID 218852-Dimethylaminopyridine

HCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 106034474'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

출처 및 근거

ORD 기록: ord-6f7972f1e6c74d02856f16625fa13267
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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