3-amino-N-ethylpiperidine → HCID 42629070, 화합물

HRID 83146

반응식

HRID 83146 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.[NH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][N:27]([CH2:31][CH3:32])[CH2:26]1>>[CH2:31]([N:27]1[CH2:28][CH2:29][CH2:30][CH:25]([NH:24][C:19](=[O:21])[C:18]2[CH:22]=[CH:23][C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:16][CH:17]=2)[CH2:26]1)[CH3:32]

참가 물질

3

반응물 2

HCID 980943-amino-N-ethylpiperidineHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

생성물 1

HCID 42629070HCID 42629070, 화합물수율 95%

실험 절차

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 3-amino-N-ethylpiperidine (1 M in DMF) instead of methylamine, to the title compound (64 mg, 95%) which was obtained as an off white foam. MS: m/e=421.3 [M+H]+.

출처 및 근거

ORD 기록
ord-ea4fd62a689b4ce1800481e276258b8a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846719B2

연결된 노트

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