(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol → 4-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine

HRID 83162

반응식

HRID 83162 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].[CH2:15]([O:22][C:23]1[CH:28]=[CH:27][NH:26][C:25](=O)[CH:24]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([O:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])[CH:24]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

3

반응물 2

HCID 2776149(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanolHCID 36077244-Benzyloxy-2(1H)-pyridone

생성물 1

HCID 426290714-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine수율 28%

실험 절차

As described for example 4, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (95 mg, 0.50 mmol) was converted using 4-benzyloxy-2(1H)-pyridone instead of 2-hydroxy-5-trifluoromethylpyridine to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 52 mg, 28%) which was obtained as a colourless oil. MS: m/e=373.1 [M+H]+.

출처 및 근거

ORD 기록
ord-2025ce0193bb489ba038c8fe32c132c4
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846719B2

연결된 노트

불러오는 중…