2-Mesitylenesulfonyl chloride → 1-(Mesitylsulfonyl)-4-(1-piperazinyl)-1H-indole Hydrochloride

HRID 8317

반응식

HRID 8317 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[C:23]1([CH3:35])[CH:28]=[C:27]([CH3:29])[CH:26]=[C:25]([CH3:30])[C:24]=1[S:31]([Cl:34])(=[O:33])=[O:32]>>[ClH:34].[C:23]1([CH3:35])[CH:28]=[C:27]([CH3:29])[CH:26]=[C:25]([CH3:30])[C:24]=1[S:31]([N:18]1[C:19]2[C:15](=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:22]=[CH:21][CH:20]=2)[CH:16]=[CH:17]1)(=[O:32])=[O:33]

참가 물질

3

반응물 2

HCID 130462-Mesitylenesulfonyl chlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

생성물 1

HCID 102955991-(Mesitylsulfonyl)-4-(1-piperazinyl)-1H-indole Hydrochloride

실험 절차

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and mesitylsulfonylchloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.10 (br, 1 H), 7.71 (d, J=5 Hz, 1 H), 7.40–7.20 (m, 3 H), 7.00–6.80 (m, 2 H), 6.51 (d, J=8 Hz, 1 H), 3.30–3.20 (m, 8 H), 2.41 (s, 6 H), 2.27 (s, 3 H); MS (ESI+) for m/z 384 (M+H)+.

출처 및 근거

ORD 기록
ord-d34fb486e4584bdcb5636a56b735f851
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087750B2

연결된 노트

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