Dichloromethane → 4-[[3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-2-fluorobenzoic acid

반응식

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([c:7]1[c:8]([F:44])[cH:9][c:10]([NH:13][C:14](=[O:15])[CH:16]2[NH:17][CH:18]([CH2:39][C:40]([CH3:41])([CH3:42])[CH3:43])[C:19]([C:29]#[N:30])([c:31]3[c:32]([F:38])[cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[CH:20]2[c:21]2[c:22]([F:28])[c:23]([Cl:27])[cH:24][cH:25][cH:26]2)[cH:11][cH:12]1)=[O:45].[CH2:53]([Cl:54])[Cl:55].[F:46][C:47]([F:48])([F:49])[C:50]([OH:51])=[O:52]>>[O:5]=[C:6]([c:7]1[c:8]([F:44])[cH:9][c:10]([NH:13][C:14](=[O:15])[CH:16]2[NH:17][CH:18]([CH2:39][C:40]([CH3:41])([CH3:42])[CH3:43])[C:19]([C:29]#[N:30])([c:31]3[c:32]([F:38])[cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[CH:20]2[c:21]2[c:22]([F:28])[c:23]([Cl:27])[cH:24][cH:25][cH:26]2)[cH:11][cH:12]1)[OH:45]