Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → [3-(3,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

반응식

C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=O)C.C(OC(C1C(C2C=CC=C(F)C=2)=NOC=1C)=O)C>>[F:19][C:14]1[CH:13]=[C:12]([C:7]2[C:6]([CH2:4][OH:3])=[C:10]([CH3:11])[O:9][N:8]=2)[CH:17]=[CH:16][C:15]=1[F:18]

참가 물질

반응물 2

HCID 22309060Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate

HCID 57466747Ethyl 3-(3,4-difluorophenyl)-5-methylisoxazole-4-carboxylate

생성물 1

HCID 68458249[3-(3,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol수율 99.6%

실험 절차

As described for example 88d, 3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (28.5 g, 107 mmol), instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, was converted to the title compound (24.0 g, 48%) which was obtained as a light yellow solid. MS: m/e=226.2 [M+H]|.

출처 및 근거

ORD 기록: ord-286fb2af2cd54ad8a39a3e5d7524469a
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846719B2

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