Pyridine-3-sulfonyl chloride → 4-(1-Piperazinyl)-1-(3-pyridinylsulfonyl)-1H-indole Hydrochloride
반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([Cl:32])(=[O:31])=[O:30])[CH:24]=1>>[ClH:32].[N:11]1([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][N:18]3[S:29]([C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)(=[O:31])=[O:30])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1참가 물질
3
실험 절차
The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 3-pyridinylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.37 (br, 1 H), 9.18 (d, J=3 Hz, 1 H), 8.86 (d, J=5 Hz, 1 H), 8.39 (d, J=8 Hz, 1 H), 7.85 (d, J=3 Hz, 1 H), 7.70–7.60 (m, 2 H), 7.27 (t, J=8 Hz, 1 H), 7.00 (d, J=3 Hz, 1 H), 6.82 (d, J=8 Hz, 1 H), 3.24 (m, 8 H); MS (ESI+) for m/z 343 (M+H)+.
출처 및 근거
- ORD 기록
- ord-81dc0901bd474a4e965d348614b33633
- 출처 데이터셋
- uspto-grants-2006_08