2-Methanesulfonylbenzene-1-sulfonyl chloride → Methyl 2-{[4-(1-piperazinyl)-1H-indol-1-yl]sulfonyl}phenyl Sulfone Hydrochloride

HRID 8327

반응식

HRID 8327 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[CH3:23][S:24]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[S:33]([Cl:36])(=[O:35])=[O:34])(=[O:26])=[O:25]>>[ClH:36].[N:11]1([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][N:18]3[S:33]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[S:24]([CH3:23])(=[O:26])=[O:25])(=[O:35])=[O:34])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

생성물 1

HCID 10139159Methyl 2-{[4-(1-piperazinyl)-1H-indol-1-yl]sulfonyl}phenyl Sulfone Hydrochloride

실험 절차

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2-methylsulfonyl-phenylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.22 (br, 1 H), 8.29 (d, J=-8 Hz, 1 H), 7.99 (t, J=8 Hz, 1 H), 7.90–7.80 (m, 2 H), 7.43 (d, J=8 Hz, 1 H), 7.3 0–7.15 (m, 2 H), 7.04 (d, J=3 Hz, 1 H), 6.85 (d, J=8 Hz, 1 H), 3.56 (s, 3 H), 3.29 (m, 8 H); MS (ESI+) for m/z 420 (M+H)+.

출처 및 근거

ORD 기록
ord-59b619bc204548cba155922be20a2f11
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087750B2

연결된 노트

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