Piperazine → 4-(1-Piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole

반응식

Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20])(=[O:13])=[O:12].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[N:21]1([C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[CH:4]=[CH:5][N:6]3[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])(=[O:13])=[O:12])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 220153344-Bromo-1-(2-methyl-benzenesulfonyl)-1H-indole

생성물 1

HCID 101572994-(1-Piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole

실험 절차

The title compound was prepared from 4-bromo-1-(2-methyl-benzenesulfonyl)-1H-indole and piperazine according to Method 1 to give 25 mg (12%) of a white solid: 1HNMR (CD3OD) δ 7.91–6.79 (m, 9H), 3.49–3.30 (m, 8H), 2.48 (s, 3H); MS (ESI) 356.1 (M+H)+; Purity (HPLC) >95%.

출처 및 근거

ORD 기록: ord-1709dad3b5804316bd81b6fe75a13e7a
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07087750B2

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