5-Methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl ester → (5-Methyl-3-(m-tolyl)isoxazol-4-yl)methanol

HRID 83362노트

반응식

HRID 83362 반응식
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=2)=[N:8][O:9][C:10]=1[CH3:11])=O)C.C(OC(C1C(C2C=CC=CC=2F)=NOC=1C)=O)C>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=2)[C:6]=1[CH2:4][OH:3]

참가 물질

3

반응물 2

HCID 223090555-Methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl esterHCID 68442729Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate

생성물 1

HCID 68444867(5-Methyl-3-(m-tolyl)isoxazol-4-yl)methanol수율 77%

실험 절차

As described for example 84d, 5-methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl ester (5.1 g, 20.8 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (3.2 g, 77%) which was obtained as a light yellow oil. MS: m/e=262.3 [M+OAc]−.

출처 및 근거

ORD 기록
ord-e2e64be71da24fe19974c9c55bd4aec2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846719B2

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