Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-(-)-2-Amino-1-propanol → 6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-((R)-2-hydroxy-1-methyl-ethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68442825 | — |
| 생성물 | 6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-((R)-2-hydroxy-1-methyl-ethyl)-nicotinamide | HCID 42630048 | 94% |
반응 단계
As described for example 254, 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (100 mg, 0.29 mmol) was converted, using D-alaninol instead of 2-amino-2-methyl-1-propanol, to the title compound (100 mg, 94%) which was obtained as a white solid. MS: m/e=402.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-aad7fd375f9940e28be4962a800a2dd1 |
| 출처 메모 | uspto-grants-2014_09 |