Isopropanol → 6-Bromo-N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}quinazolin-4-amine

반응식

[Br:1][c:2]1[cH:3][c:4]2[c:5]([Cl:12])[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1.[CH:30]([OH:31])([CH3:32])[CH3:33].[Cl:13][c:14]1[cH:15][c:16]([NH2:17])[cH:18][cH:19][c:20]1[O:21][CH2:22][c:23]1[cH:24][c:25]([F:29])[cH:26][cH:27][cH:28]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([NH:17][c:16]3[cH:15][c:14]([Cl:13])[c:20]([O:21][CH2:22][c:23]4[cH:24][c:25]([F:29])[cH:26][cH:27][cH:28]4)[cH:19][cH:18]3)[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1

참가 물질

반응물 3

HCID 3776Isopropanol

HCID 70592633-Chloro-4-(3-fluorobenzyloxy)aniline

HCID 167703106-Bromo-4-chloro-quinazoline

생성물 1

HCID 247378566-Bromo-N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}quinazolin-4-amine

출처 및 근거

ORD 기록: ord-29a697ae61c74bb2b780163ee55c9049
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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