Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorosuccinimide → 4-Fluoro-N-hydroxybenzimidoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | Benzaldehyde, p-fluoro-, oxime | HCID 5372466 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Fluoro-N-hydroxybenzimidoyl chloride | HCID 5706360 | 100.2% |
반응 단계
To a solution of (E)- and/or (Z)-4-fluoro-benzaldehyde oxime (100 g, 719 mmol) in DMF (500 mL) was added N-chlorosuccinimide (110 g, 791 mmol) portionwise keeping the temperature below 70° C. The reaction mixture was stirred at room temperature for 2.5 h and then extracted with tert-butyl methyl ether to afford the title compound (125 g, 100%) which was obtained as a yellow oil. MS: m/e=173.1 [M]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3e0b07dfc2d0475b8709a2e52fbf575e |
| 출처 메모 | uspto-grants-2014_09 |