Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopropanol → 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-1-methyl-ethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopropanol | HCID 5126 | — |
| 반응물 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 66599292 | — |
| 반응물 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 68443977 | — |
| 생성물 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-1-methyl-ethyl)-nicotinamide | HCID 42630420 | 71% |
반응 단계
As described for example 220, 6-[3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (100 mg, 0.31 mmol) was converted, instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester, using rac-2-amino-1-propanol instead of 3-amino-1-propanol, to the title compound (80 mg, 71%) which was obtained as a colourless gum. MS: m/e=372.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-97abb7feeca04d67b0398e5880faa85b |
| 출처 메모 | uspto-grants-2014_09 |